Risk factors for non-sentinel lymph node metastasis in HR+/HER2- breast cancer with cN0

Researchers reviewed data from patients with HR+ HER2- breast cancer who underwent axillary lymph node dissection due to positive sentinel lymph nodes. They found a significant association between non-sentinel lymph node metastasis and the number of positive nodes, sentinel lymph node positive ratio, and primary tumor size. They also found that a sentinel lymph node ratio of greater than 0.55 was independently associated with non-sentinel lymph node metastasis. They concluded that in patients with HR+ HER2- breast cancer who are cN0 and who have a positive sentinel lymph node ratio of 0.55 or greater, axillary lymph node dissection should be considered.