From the publishers of JADPRO

HR+ HER2- Breast Cancer Resource Center

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Real-world outcomes of elacestrant in ER+, HER2−, ESR1-mutant metastatic breast cancer

Last Updated: Tuesday, March 10, 2026

In a real-world analysis of claims data from 306 patients with ER+ HER2- metastatic breast cancer harboring an ESR1 mutation who were treated with elacestrant, elacestrant demonstrated a durable benefit, particularly in earlier lines and in patients with prolonged prior endocrine therapy exposure. 

Clinical Cancer Research
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