High chromosomal instability is associated with higher 10-year risks of recurrence for hormone receptor-positive, human epidermal growth factor receptor 2-negative breast cancer patients: Clinical evidence from a large-scale, multiple-site, retrospective study

In a retrospective longitudinal cohort study, researchers evaluated incidence, treatment, and survival data from patients in with high-risk HER2- early breast cancer in Alberta, Canada. They found that overall survival was significantly worse among patients who were older, had grade 3 histology, had stage III disease, or had nodal involvement, which indicates some unmet clinical needs.