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HR+ HER2- Breast Cancer Resource Center

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CDK4 selective inhibition improves preclinical anti-tumor efficacy and safety

Last Updated: Monday, April 14, 2025

Researchers evaluated atirmociclib (PF-07220060), a next-generation CDK4 selective inhibitor. They found that dose intensification led to greater CDK4 inhibition and deeper antitumor responses. Combinatorial agents also further increased atirmociclib’s antitumor efficacy.

Cancer Cell
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