CDK4/6 inhibitor-induced liver injury: Clinical phenotypes and role of corticosteroid treatment

Researchers conducted a retrospective study of patients who experienced liver toxicity following the use of CDK4/6 inhibitors. They reported on 22 cases of grade 3-4 hepatitis induced by ribociclib and abemaciclib. They concluded that although CD4/6 inhibitor-induced hepatitis is poorly described in the literature, the data support adding these drugs to the drug-induced autoimmune-like hepatitis category.