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HR+ HER2- Breast Cancer Resource Center

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CDK4/6 as a therapeutic target in HR+/HER2- breast cancer cells—Current treatment status

Last Updated: Tuesday, September 9, 2025

An overview of clinical applications, toxicity profiles, and future directions for CDK4/6 inhibitors. This analysis reviews data on palbociclib, ribociclib, and abemaciclib from trials such as PALOMA-1,2,3; MONALEESA-1,2,3,7; MONARCH-1,2,3; MonarchE; and NATALEE.

Cancers (Basel)
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