Hypophosphatemia Due to Increased Effector Cell Metabolic Activity is Associated with Neurotoxicity Symptoms in CD19-Targeted CAR T-cell Therapy

Immune effector cell-associated (ICANS) presents similarly to hypophosphatemia as confusion, aphasia, seizures, weakness, somnolence, and coma. Because hypophosphatemia can result from sudden increases in metabolic demand for phosphorylated intermediates, researchers examined whether CAR T-cell effector metabolic activity is associated with increased extracellular phosphate consumption. This study concluded that phosphorous level monitoring could be important in ICANS diagnosis.