Advancing chimeric antigen receptor T-cell therapy frontiers in glioblastoma: Navigating the current landscape from clinical hurdles to breakthrough strategies

In a clinical review, researchers discuss ongoing and recently completed trials highlighting emerging CAR-T strategies in the treatment of glioblastoma. They discuss strategies to enhance CAR-T trafficking, persistence, and function in the glioblastoma microenvironment as well as next-generation CAR-T therapies aimed to improve durability and scalability.