Updates on mechanisms of disease progression in precursor myeloma: Monoclonal gammopathy of undermined significance and smoldering myeloma

The update discusses the premalignant stages of multiple myeloma, monoclonal gammopathy of undetermined significance, and smoldering multiple myeloma (SMM), and the detection of monoclonal gammopathy of indeterminate potential. It highlights risk stratification models, genomic studies, immune alterations, and epigenetics for predicting progression. It also mentions therapies for high-risk SMM and the need for future research.