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Multiple Myeloma Resource Center

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Community hematologist/oncologist perspectives on minimal residual disease testing in patients with multiple myeloma

Last Updated: Wednesday, August 27, 2025

The opinions of community hematologist/oncologists were sought regarding minimal residual disease (MRD) testing in multiple myeloma patients, examining the factors influencing its use, barriers to its adoption, and how results impact treatment decisions. A survey of 22 practitioners revealed that while most were comfortable with MRD testing, actual usage was low. The primary motivation for testing was monitoring remission status, but logistical challenges in sending samples were the main obstacle. The study concludes that reducing these barriers and providing more clinical data are crucial to developing guidelines and improving the integration of MRD testing into practice.

Future Oncology
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News & Literature Highlights

US Food & Drug Administration

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Clinica Chimica Acta; International Journal of Clinical Chemistry

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New England Journal of Medicine

Teclistamab in multiple myeloma with one to three previous lines of therapy

Annals of Medicine and Surgery

Statin exposure after multiple myeloma diagnosis and risk of all-cause mortality, venous thromboembolism, pathological fractures, and acute kidney injury: a propensity score-matched retrospective cohort study

The Lancet

Mezigdomide, carfilzomib, and dexamethasone versus carfilzomib and dexamethasone in patients with relapsed or refractory multiple myeloma (SUCCESSOR-2): a phase 3, open-label, randomised controlled trial

American Journal of Blood Research

Therapy-related B-cell acute lymphoblastic leukemia after treatment for multiple myeloma

Cancer Epidemiology

Occupational pesticide exposure and association of monoclonal gammopathy of undetermined significance in the Western Macroregion of Paraná

Molecular and Cellular Probes

The role of RNA modifications in the pathological mechanisms and therapeutic targeting of multiple myeloma

The FEBS Journal

Understanding and addressing resistance to IMiDs immunomodulatory compounds in multiple myeloma

Transplantation and Cellular Therapy

Trial in progress: QUINTESSENTIAL-2—a phase 3 Study of arlocabtagene autoleucel versus standard of care in adult patients with relapsed and refractory multiple myeloma (RRMM) exposed to lenalidomide

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