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News & Literature Highlights
Cancer Treatment Reviews
First versus second-generation molecular profiling tests: How both can guide decision-making in early-stage hormone-receptor positive breast cancers?
npj Precision Oncology
Successful unconventional precision treatment of inflammatory hormone receptor-positive breast cancer guided by molecular profiling
BMC Women’s Health
Comparison of the efficacy and safety of docetaxel plus capecitabine versus docetaxel plus epirubicin for human epidermal growth factor 2 -negative breast cancer: A meta-analysis
The Breast
Awareness of genomic testing among patients with breast cancer in Europe
Breast Cancer Research and Treatment
PTEN inactivating mutations are associated with hormone receptor loss during breast cancer recurrence
Cancer Cell
CDK4 selective inhibition improves preclinical anti-tumor efficacy and safety
Chinese Journal of Cancer Research
Clinicopathological and molecular features of HR + /HER2 - breast cancer patients with distinct endocrine resistance patterns
European Journal of Nuclear Medicine and Molecular Imaging
Predictive and prognostic value of 18F-FES PET/CT for patients with recurrent or metastatic breast cancer treated with endocrine therapy plus cyclin-dependent kinase 4/6 inhibitors
Future Oncology
Real-world study of patients with HR+/ HER2- metastatic breast cancer treated with palbociclib and fulvestrant
Cancer Letters
TFAP2C-DDR1 axis regulates resistance to CDK4/6 inhibitor in breast cancer
European Journal of Cancer
Metastasis-directed stereotactic radiotherapy and systemic treatment continuation for patients with oligoprogressive metastatic breast cancer
Journal of Cachexia, Sarcopenia, and Muscle
Low skeletal muscle radiodensity predicts response to CDK4/6 inhibitors plus aromatase inhibitors in advanced breast cancer
Nature Communications
Lerociclib plus fulvestrant in patients with HR+/HER2- locally advanced or metastatic breast cancer who have progressed on prior endocrine therapy: LEONARDA-1 a phase III randomized trial
Drugs
Efficacy and safety of CDK4/6 inhibitors: A focus on HR+/HER2- early breast cancer
Journal of Clinical Oncology
Datopotamab deruxtecan versus chemotherapy in previously treated inoperable/metastatic hormone receptor-positive human epidermal growth factor receptor 2-negative breast cancer: Primary results from TROPION-Breast01
U.S. Food and Drug Administration
FDA approves datopotamab deruxtecan-dlnk for unresectable or metastatic, HR-positive, HER2-negative breast cancer
Therapeutic Advances in Medical Oncology
Elacestrant plus alpelisib in an ESR1 and PIK3CA co-mutated and heavily pretreated metastatic breast cancer: The first case report for combination efficacy and safety
The Journal of Pathology. Clinical Research
High chromosomal instability is associated with higher 10-year risks of recurrence for hormone receptor-positive, human epidermal growth factor receptor 2-negative breast cancer patients: Clinical evidence from a large-scale, multiple-site, retrospective study
Clinical Breast Cancer
Real world evidence study to assess incidence, treatment patterns, clinical outcomes, and health care resource utilization in early-stage, high-risk HER2-negative breast cancer in Alberta, Canada
Oncology Research and Treatment
Palbociclib in combination with either aromatase inhibitors or fulvestrant for patients with advanced HR+/HER2- breast cancer in Germany: Final results of the phase 2 multicohort INGE-B trial
Therapeutic Advances in Medical Oncology
Everolimus treatment in patients with hormone receptor-positive and human epidermal growth factor receptor 2-negative advanced breast cancer and a predictive model for its efficacy: A multicenter real-world study
Cureus
Dormancy leading to late recurrence in breast cancer: A case of hormone receptor-positive supraclavicular metastasis 10 years after the initial treatment
Frontiers in Immunology
Advances in Trop-2 targeted antibody-drug conjugates for breast cancer: Mechanisms, clinical applications, and future directions
Clinical Cancer Research
Hormone receptor positive HER2-negative/MammaPrint high-2 breast cancers closely resemble triple negative breast cancers
Cancer Medicine
PIK3CA mutational status in tissue and plasma as a prognostic biomarker in HR+/HER2- breast cancer
International Immunopharmacology
Pirfenidone inhibits CCL2-mediated Treg chemotaxis induced by palbociclib and fulvestrant in HR+/HER2- breast cancer
Current Medical Research and Opinion
Cost-effectiveness of CDK4/6 inhibitors in HR+/HER2− metastatic breast cancer: A systematic review and meta-analysis
ESMO Open
Real-world treatment patterns and outcomes in patients with HR+/HER2- metastatic breast cancer treated with chemotherapy in the United States
Oncology Letters
First-line endocrine therapy for hormone receptor positive and HER 2 negative metastatic breast cancer: A Bayesian network meta analysis
Translational Oncology
Excavating regulated cell death signatures to predict prognosis, tumor microenvironment and therapeutic response in HR+/HER2- breast cancer
Frontiers in Immunology
Efficacy and safety of different regimens of neoadjuvant therapy in patients with hormone receptor-positive, HER2-negative breast cancer: A network meta-analysis
American Journal of Clinical Oncology
Efficacy and safety of abemaciclib in combination with endocrine therapy for HR+/HER2- advanced or metastatic breast cancer: A systematic review and meta-analysis
JHEP Reports
CDK4/6 inhibitor-induced liver injury: Clinical phenotypes and role of corticosteroid treatment
npj Breast Cancer
A phase 3 study (PATHWAY) of palbociclib plus tamoxifen in patients with HR-positive/HER2-negative advanced breast cancer
JAMA Surgery
Electronic health record-based nudge intervention and axillary surgery in older women with breast cancer: A nonrandomized controlled trial
Future Oncology
The NEOLETRIB trial: Neoadjuvant treatment with letrozole and ribociclib in ER-positive, HER2-negative breast cancer
Anticancer Research
Risk factors for non-sentinel lymph node metastasis in HR+/HER2- breast cancer with cN0
Radiology Case Reports
Palbociclib and fulvestrant combined regimen induced prolonged bone metastasis control of stage IV HR+/HER2- breast cancer: A case report
Reviews in Cardiovascular Medicine
Risk of cardiovascular events with cyclin-dependent kinases 4 and 6 (CDK 4/6) inhibitors among patients with advanced breast cancer: A systematic review and network meta-analysis
Oncology and Therapy
Palbociclib in HR-positive, HER2-negative advanced/metastatic breast cancer: A systematic scoping review of real-world evidence from countries outside of Western regions that are underrepresented in clinical trials
Journal of Clinical Medicine
Novel treatment strategies for hormone receptor (HR)-positive, HER2-negative metastatic breast cancer
Cancers (Basel)
Social determinants of health and other predictors in initiation of treatment with CDK4/6 inhibitors for HR+/HER2- metastatic breast cancer
Current Opinion in Oncology
Controversies on chemotherapy for early HR+/HER2- breast cancer: The role of anthracyclines and dose intensification
npj Breast Cancer
Impact of dose reductions on adjuvant abemaciclib efficacy for patients with high-risk early breast cancer: analyses from the monarchE study
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Case Studies
Genetic Testing and Risk Intervention Based on Family History of Early-Onset Breast Cancer
First-Line Treatment for Metastatic ER+ HER2- Breast Cancer
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Quizzes
Test your knowledge of genetic testing and risk intervention based on family history of early-onset breast cancer
Test your knowledge on HR-positive, HER2-negative breast cancer
Test your knowledge on first-line treatment for metastatic ER+ HER2- breast cancer