Higher doses of tisagenlecleucel associate with improved outcomes: a report from the pediatric real-world CAR consortium.

Last Updated: Wednesday, October 12, 2022

There is a wide dose range for tisagenlecleucel, which has shown strong complete response for patients up to the age of 26 with B-cell acute lymphoblastic leukemia (B-ALL). This article discusses impact of a higher dose on tisagenlecleucel efficacy and associated toxicity.

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Higher doses of tisagenlecleucel associate with improved outcomes: a report from the pediatric real-world CAR consortium.

JAMA Network Open

Cardiovascular events after chimeric antigen receptor T-cell therapy for advanced hematologic malignant neoplasms: A meta-analysis

Blood Advances

Outcome of patients with large B-cell lymphoma treated with tafasitamab plus lenalidomide either before or after CAR T-cell therapy

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Access barriers to anti-CD19+ CAR T-cell therapy for NHL across a community transplant and cellular therapy network

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EASIX and m-EASIX predict CRS and ICANS in pediatric and AYA patients post CD19-CAR T cell therapy

Blood Advances

Local radiation enhances systemic CAR T cell efficacy by augmenting antigen cross-presentation and T-cell infiltration

Blood Advances

Feasibility and favorable responses following investigational CAR T-Cell therapy for relapsed and refractory infant ALL

Bone Marrow Transplantation

Role of bridging RT in relapsed/refractory diffuse large B-cell lymphoma undergoing CAR-T therapy: A multicenter study

Frontiers in Immunology

Chimeric antigen receptor T-cell therapy in relapsed or refractory mantle cell lymphoma: A systematic review and meta-analysis

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