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Isatuximab subcutaneous by on-body delivery system vs isatuximab intravenous plus pomalidomide and dexamethasone in relapsed/refractory multiple myeloma: Phase 3 IRAKLIA study

Last Updated: Thursday, June 26, 2025

The IRAKLIA phase 3 study found that isatuximab subcutaneous (OBDS) is non-inferior to intravenous for relapsed/refractory multiple myeloma, regarding efficacy and pharmacokinetics. OBDS showed fewer infusion reactions (1.5% vs 25.0%) and good tolerability, supporting its potential to improve practice efficiency. 

Journal of Clinical Oncology
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Isatuximab subcutaneous by on-body delivery system vs isatuximab intravenous plus pomalidomide and dexamethasone in relapsed/refractory multiple myeloma: Phase 3 IRAKLIA study

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