Characterization and verification of MMP family members as potential biomarkers in kidney clear cell renal carcinoma

Renal cell carcinoma can arise from lesions in the renal epithelium and is associated with an unfavorable prognosis. Among these cases, over 70% are classified as kidney renal clear cell carcinoma (KIRC). To understand the pathogenesis of KIRC, various tools, software, and molecular analysis were used to identify a small set of hub genes. Four MMP gene family members, MMP2, MMP9, MMP14, and MMP16, may serve as therapeutic target and molecular biomarker in KIRC.