Unraveling obesity and multiple myeloma: Insights from epidemiology and molecular mechanisms

Obesity is a modifiable risk factor for multiple myeloma, increasing its incidence, progression from precursor stages, and mortality. This link is driven by chronic inflammation and altered adipokine signaling. Lifestyle changes (diet, physical activity) and pharmacological strategies (e.g., metformin, GLP-1 RAs) show promise in prevention and management.