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Multiple Myeloma Resource Center

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EHA-EMN Evidence-Based Guidelines for diagnosis, treatment and follow-up of patients with multiple myeloma

Last Updated: Thursday, September 25, 2025

EHA–EMN Evidence-Based Guidelines for the diagnosis, treatment, and follow-up of multiple myeloma (MM) patients have been updated, incorporating advancements from January 2021 to May 2025. It details updated criteria for disease staging and prognosis, including the R2-ISS system and novel biomarkers like minimal residual disease. The guidelines provide key treatment recommendations for newly diagnosed MM (transplant-eligible and ineligible patients), relapsed and/or refractory MM, and smoldering multiple myeloma, reflecting recent drug approvals and clinical trial results, and comprehensive supportive care guidelines for common MM complications and adverse events.

Nature Reviews. Clinical Oncology
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