Deciphering and targeting oncogenic pathways through integrated approaches and amino acid metabolism in hematologic malignancies

Breakthroughs in treating blood cancers include precision medicine as a transformative approach. Genomics, gene editing (like CRISPR), and immunotherapies (such as CAR-T cells) are revolutionizing diagnostics and tailored treatments. Researchers investigated the crucial role of amino acid metabolism and various cell signaling pathways in cancer progression, identifying them as promising therapeutic targets. Multiple myeloma, in particular, has complex genomic aberrations and metabolic dependencies that make it a candidate for these novel, integrated approaches.