Thrombosis in patients with post-polycythemia vera myelofibrosis: incidence and risk factors

In an analysis of clinical and laboratory characteristics of 163 patients with post-polycythemia vera (PV) myelofibrosis (MF), thrombosis-free survival was lower among patients with post-PV MF compared with PV (P < .0001). Risk factors for thrombosis included palpable splenomegaly (HR 3.284, 95% CI: 1.373-7.855; P = .008), age 60 or older (HR 1.604, 95% CI: 1.004-2.56; P = .048), and history of thrombosis (HR 2.767, 95% CI: 1.735-4.412; P < 0.001).