The clinical dilemma of JAK inhibitor failure in myelofibrosis: Predictive characteristics and outcomes

Last Updated: Friday, September 2, 2022

This review article details the pivotal trials leading to the approvals of JAK inhibitors ruxolitinib and fedratinib, as well as the high frequency of discontinuation of these therapies due to adverse events or progressive disease. Ongoing studies of non-JAK inhibitor therapies, including pelabresib, navitoclax, parsaclisib, navtemadlin, and imetelstat, are also highlighted.

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Current Hematologic Malignancy Reports

Myeloproliferative neoplasms in children, adolescents, and young adults

British Journal of Haematology

‘MPN Genomic Calculator’: real‐life use in a young population with essential thrombocythaemia

Leukemia

Significant association of cutaneous adverse events with hydroxyurea: results from a prospective non-interventional study in BCR-ABL1-negative myeloproliferative neoplasms (MPN) - on behalf of the German Study Group-MPN

Thrombosis Research

Patient outcomes in myeloproliferative neoplasm-related thrombosis: Insights from the National Inpatient Sample

British Journal of Haemtology

Real‐world non‐interventional long‐term post‐authorisation safety study of ruxolitinib in myelofibrosis

Cancer Medicine

Depressive symptoms and myeloproliferative neoplasms: Understanding the confounding factor in a complex condition

Cancers

Novel concepts of treatment for patients with myelofibrosis and related neoplasms

Expert Review of Hematology

Developing strategies to reduce the duration of therapy for patients with myeloproliferative neoplasms

European Society for Medical Oncology (ESMO) Congress 2021 Abstract

Final results of a phase II study of tipifarnib in chronic myelomonocytic leukemia (CMML) and other myelodysplastic/myeloproliferative neoplasms (MDS/MPN)

European Society for Medical Oncology (ESMO) Congress 2021 Abstract

Treatment outcomes and antibody immunity to SARS-CoV-2 in patients with hematological malignancies

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