Ruxolitinib treatment in myelofibrosis and polycythemia vera causes suboptimal humoral immune response following standard and booster vaccination with BNT162b2 mRNA COVID-19 vaccine

Last Updated: Tuesday, April 11, 2023

Data from a prospective study of 43 patients with either myelofibrosis or polycythemia vera receiving ruxolitinib showed that 32.5% did not develop any response after two SARS-CoV-2 mRNA vaccine boosters. After a third booster, 80% produced antibodies above the threshold positivity, yet still well below that reported for healthy individuals.

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Current Hematologic Malignancy Reports

Myeloproliferative neoplasms in children, adolescents, and young adults

British Journal of Haematology

‘MPN Genomic Calculator’: real‐life use in a young population with essential thrombocythaemia

Leukemia

Significant association of cutaneous adverse events with hydroxyurea: results from a prospective non-interventional study in BCR-ABL1-negative myeloproliferative neoplasms (MPN) - on behalf of the German Study Group-MPN

Thrombosis Research

Patient outcomes in myeloproliferative neoplasm-related thrombosis: Insights from the National Inpatient Sample

British Journal of Haemtology

Real‐world non‐interventional long‐term post‐authorisation safety study of ruxolitinib in myelofibrosis

Cancer Medicine

Depressive symptoms and myeloproliferative neoplasms: Understanding the confounding factor in a complex condition

Cancers

Novel concepts of treatment for patients with myelofibrosis and related neoplasms

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European Society for Medical Oncology (ESMO) Congress 2021 Abstract

Final results of a phase II study of tipifarnib in chronic myelomonocytic leukemia (CMML) and other myelodysplastic/myeloproliferative neoplasms (MDS/MPN)

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