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MPN Resource Center


Prognostic significance of the Myelodysplastic Syndrome-Specific Comorbidity Index (MDS-CI) in patients with myelofibrosis: A retrospective study

Last Updated: Monday, December 4, 2023

Results from a retrospective chart review of patients with myelofibrosis who had not received allogeneic stem cell transplantation suggest that the Myelodysplastic Syndrome-Specific Comorbidity Index is a useful tool to identify patients with myelofibrosis with an increased vulnerability due to comorbidities. The MDS-CI added prognostic information after inclusion as a categorical variable in a multivariate model together with the dichotomized DIPSS or the dichotomized MIPSS70: MDS-CI high HR 14.64 (95% CI 4.42; 48.48), p = 0.0002, and MDS-CI intermediate HR 1.97 (95% CI 0.96; 4.03), p = 0.065, and MDS-CI high HR 19.65 (95% CI 4.71; 81.95), p < 0.001, and MDS-CI intermediate HR 1.063 (95% CI 0.65; 4.06), p = 0.2961, respectively. 

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