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Momelotinib improves outcomes in pretreated myelofibrosis

Last Updated: Wednesday, February 9, 2022

According to data from the randomized phase 3 MOMENTUM trial, the selective, orally bioavailable JAK1, JAK2 and ACVR1/ALK2 inhibitor momelotinib has demonstrated statistically significant benefit in total symptom score compared with danazol among patients with myelofibrosis previously treated with a JAK inhibitor. Twenty-five percent of patients in the momelotinib arm achieved total symptom score reduction of at least 50%, compared with 9% in the danazol arm (P = .0095).

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