Hepcidin Mimetic (PTG-300) Reverses Iron Deficiency While Controlling Hematocrit in Polycythemia Vera Patients

Last Updated: Friday, March 12, 2021

Phase 2 data presented during the 2020 ASH Annual Meeting show that hepcidin-mimetic PTG-300 is effective at controlling hematocrit and reversing iron deficiency in patients with polycythemia vera. During treatment with PTG-300, patients’ serum ferritin levels increased progressively toward normal, while transferrin saturation and serum iron values increased modestly but remained below normal ranges.

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