FDA approves JAK inhibitor momelotinib for myelofibrosis with anemia

Last Updated: Wednesday, November 1, 2023

Based on data from the SIMPLIFY-1 trial, the U.S. Food and Drug Administration approved momelotinib—a JAK1/JAK2 and activin A receptor type 1 (ACVR1) inhibitor—for the treatment of intermediate- or high-risk myelofibrosis, including primary myelofibrosis or secondary myelofibrosis (post-polycythemia vera and post-essential thrombocythemia), in adults with anemia. This is the first and only treatment indicated for patients with myelofibrosis and anemia.

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British Journal of Haematology

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Leukemia

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