Atrial fibrillation and peripheral arterial disease define MPN patients with very high risk of thrombosis

Data from a large cohort of MPN patients suggest that atrial fibrillation (AF) and peripheral arterial disease (PAD) are criteria for high-risk of thrombosis, hemorrhage, and death. Postdiagnosis thrombotic events were observed in 31.3% of patients who experienced AF (p = 0.002, OR = 1.80 [1.23; 2.61]), 35.8% of those who experienced PAD (p = 0.002, OR = 2.21 [1.31; 3.67]), and 62.1% of those who experienced both AF and PAD (p < 0.0001, OR = 6.47 [2.83; 15.46]) compared with 20.1% of the no-AF/no-PAD cohort. Postdiagnosis hemorrhagic events were also identified in 17.9%, 16%, 24.1%, and 10.1% of the AF, PAD, AF and PAD, and no-AF or PAD cohorts, respectively (p = 0.003).