Neutropenic Enterocolitis: A Rare Complication of Sacituzumab Govitecan

Neutropenic enterocolitis (NE) is a rare form of inflammatory colitis seen in severely neutropenic patients. Patients with NE typically have severe neutropenia (absolute neutrophil count [ANC] < 500/mm³) in the setting of exposure to cytotoxic chemotherapy. Taxanes have traditionally been associated with NE, but there has been a growing amount of literature linking a variety of other chemotherapeutic agents. The authors report a case of NE in a patient with metastatic triple-negative breast cancer receiving sacituzumab govitecan and its successful management.