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Highlights from the 2025 ASCO Annual Meeting: Part 1
Last Updated: Friday, July 25, 2025
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News & Literature Highlights
Journal of Clinical Oncology
INAVO120: Phase III trial final overall survival (OS) analysis of first-line inavolisib (INAVO)/placebo (PBO) + palbociclib (PALBO) + fulvestrant (FULV) in patients (pts) with PIK3CA-mutated, hormone receptor-positive (HR+), HER2-negative (HER2–), endocrine-resistant advanced breast cancer (aBC)
Journal of Clinical Oncology
VERITAC-2: A global, randomized phase 3 study of ARV-471, a proteolysis targeting chimera (PROTAC) estrogen receptor (ER) degrader, vs fulvestrant in ER+/human epidermal growth factor receptor 2 (HER2)- advanced breast cancer
Journal of Clinical Oncology
A double-blind placebo controlled randomized phase III trial of fulvestrant and ipatasertib as treatment for advanced HER2-negative and estrogen receptor positive (ER+) breast cancer following progression on first line CDK 4/6 inhibitor and aromatase inhibitor: The CCTG/BCT MA.40/FINER study (NCT04650581)
Biomedicines
Real-world analysis of adherence to abemaciclib and endocrine therapy in women with HR+/HER2- breast cancer
Journal of Clinical Oncology
Camizestrant + CDK4/6 inhibitor for the treatment of emergent ESR1 mutations during first-line endocrine-based therapy and ahead of disease progression in patients with HR+/HER2– advanced breast cancer: Phase 3, double-blind ctDNA-guided SERENA-6 trial
Journal of Clinical Oncology
Patient-reported outcomes (PROs) in patients with ER+, HER2- advanced breast cancer (ABC) treated with imlunestrant, investigator’s choice standard endocrine therapy, or imlunestrant + abemaciclib: Results from the phase III EMBER-3 trial
Journal of Clinical Oncology
The TRADE study: A phase 2 trial to assess the tolerability of abemaciclib dose escalation in early-stage HR+/HER2- breast cancer
The Breast
Real-world risk of recurrence and treatment outcomes with adjuvant endocrine therapy in patients with stage II-III HR+/HER2- early breast cancer
Radiographics
Breast cancer surveillance in patients with a personal history of breast cancer: Updates and controversies
Frontiers in Oncology
Real-world effectiveness of CDK4/6i in first-line treatment of HR+/HER2- advanced/metastatic breast cancer: Updated systematic review
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Case Studies
Genetic Testing and Risk Intervention Based on Family History of Early-Onset Breast Cancer
First-Line Treatment for Metastatic ER+ HER2- Breast Cancer
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Quizzes
Test your knowledge of genetic testing and risk intervention based on family history of early-onset breast cancer
Test your knowledge on HR-positive, HER2-negative breast cancer
Test your knowledge on first-line treatment for metastatic ER+ HER2- breast cancer