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HR+ HER2- Breast Cancer Resource Center

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The prognostic and predictive impact of ctDNA levels in patients with advanced breast cancer enrolled on the plasmaMATCH trial

Last Updated: Tuesday, March 10, 2026

Researchers assessed ctDNA baseline levels in patients with advanced breast cancer enrolled in the plasmaMATCH trial. They found that baseline low ctDNA levels may predict response to targeted therapy, potentially suggesting shared mechanisms between high ctDNA release and resistance to therapy. 

Clinical Cancer Research
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