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HR+ HER2- Breast Cancer Resource Center

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PTEN inactivating mutations are associated with hormone receptor loss during breast cancer recurrence

Last Updated: Monday, April 14, 2025

In a retrospective study, researchers evaluated data from 112 patients with primary ER+ HER2- breast cancer who developed local or distant recurrence. They found that increased PI3K/AKT/PTEN pathway signaling was associated with hormone independence in recurrent disease.

Breast Cancer Research and Treatment
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