From the publishers of JADPRO

HR+ HER2- Breast Cancer Resource Center

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OPERA-01: A phase III study of palazestrant for ER+, HER2- advanced breast cancer after CDK4/6 inhibitor therapy

Last Updated: Wednesday, February 11, 2026

OPERA-01 is an ongoing phase III clinical trial evaluating the safety and efficacy of palazestrant monotherapy compared with standard-of-care endocrine therapy among patients with ER+ HER2- advanced breast cancer whose disease advanced following treatment with endocrine therapy plus a CDK4/6 inhibitor.

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