Novel treatment strategies for hormone receptor (HR)-positive, HER2-negative metastatic breast cancer

Last Updated: Thursday, August 1, 2024

There is current disagreement on the best treatment plan for patients with HR+ HER2- breast cancer whose disease progresses after receiving combination CDK4/6 inhibitors and endocrine therapy. To help meet this research need, investigators used clinical evidence and genomic profiling to provide new insight into the use of endocrine therapy and other targeted therapies for the treatment of this patient population.

Journal of Clinical Medicine

The Breast

Awareness of genomic testing among patients with breast cancer in Europe

BMC Women’s Health

Comparison of the efficacy and safety of docetaxel plus capecitabine versus docetaxel plus epirubicin for human epidermal growth factor 2 -negative breast cancer: A meta-analysis

npj Precision Oncology

Successful unconventional precision treatment of inflammatory hormone receptor-positive breast cancer guided by molecular profiling

Cancer Treatment Reviews

First versus second-generation molecular profiling tests: How both can guide decision-making in early-stage hormone-receptor positive breast cancers?

European Journal of Nuclear Medicine and Molecular Imaging

Predictive and prognostic value of 18F-FES PET/CT for patients with recurrent or metastatic breast cancer treated with endocrine therapy plus cyclin-dependent kinase 4/6 inhibitors

Chinese Journal of Cancer Research

Clinicopathological and molecular features of HR + /HER2 - breast cancer patients with distinct endocrine resistance patterns

Cancer Cell

CDK4 selective inhibition improves preclinical anti-tumor efficacy and safety

Breast Cancer Research and Treatment

PTEN inactivating mutations are associated with hormone receptor loss during breast cancer recurrence

Journal of Cachexia, Sarcopenia, and Muscle

Low skeletal muscle radiodensity predicts response to CDK4/6 inhibitors plus aromatase inhibitors in advanced breast cancer

European Journal of Cancer

Metastasis-directed stereotactic radiotherapy and systemic treatment continuation for patients with oligoprogressive metastatic breast cancer

HR+ HER2- Breast Cancer Resource Center