Multiomic profiling of ER-positive HER2-negative breast cancer reveals markers associated with metastatic spread

Researchers used advances in proteomic profiling of tumors to investigate new subtypes and molecular tumor features associated with metastatic spread. They quantified 13,571 protein groups, 7,107 phosphopeptides, and 13,085 expressed genes in at least 70% of the evaluated samples. Through this, they identified potential new subtypes with differential immune infiltration patterns and survival and identified several potential protein markers of both lymph node and distant metastases.