Excavating regulated cell death signatures to predict prognosis, tumor microenvironment and therapeutic response in HR+/HER2- breast cancer

Researchers analyzed 12 types of regulated cell death (RCD) patterns to construct a novel RCD prognostic scoring system (CDScore) based on six critical genes (LEF1, SLC7A11, SFRP1, IGFBP6, CXCL2, and STXBP1) in HR+ HER2- breast cancer. They used CDScore, patient age, and TNM stage to create a nomogram to predict patient prognosis. The researchers found that the nomogram was satisfactory at predicting overall survival, and that patients in CDScore high group tended to have disease that was resistant to standard chemotherapy and targeted therapies.