CDK4 selective inhibition improves preclinical anti-tumor efficacy and safety
Last Updated: Monday, April 14, 2025
Researchers evaluated atirmociclib (PF-07220060), a next-generation CDK4 selective inhibitor. They found that dose intensification led to greater CDK4 inhibition and deeper antitumor responses. Combinatorial agents also further increased atirmociclib’s antitumor efficacy.
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