Predictors and significance of kidney dysfunction in patients with chronic graft-versus-host disease

According to data from a cross-sectional chronic GVHD natural history study, history of cyclosporine use (OR 2.19, 95% CI: 1.13-4.25), angiotensin receptor blocker use (OR 5.57, 95% CI: 1.49-20.84), proteinuria (OR 2.39, 95% CI: 1.19-4.79), lower C-reactive protein (OR 0.95, 95% CI: 0.91-0.99), lower C3 (OR 0.98, 95% CI: 0.97-0.99), and lower hemoglobin (OR 0.70, 95% CI: 0.58-0.84) were jointly associated with kidney dysfunction. Further, overall survival was lower in those patients with moderate-severe kidney dysfunction (P = 0.015).