Metabolic syndrome prevalence and impact on outcomes in patients with chronic graft-versus-host disease

According to data from the cross-sectional NIH cGVHD Natural History Study, among patients with chronic GVHD, higher circulating erythrocyte sedimentation rate, C-reactive protein, and creatinine concentrations, as well as lower estimated glomerular filtration rate, were associated with components of metabolic syndrome (P < 0.001; P < 0.004; P = 0.02; P = 0.002; respectively). Patients with metabolic syndrome had no statistical differences in survival or non-relapse mortality (NRM), compared to those without (5-year OS: 64% [95% CI: 54.8%-71.8%] vs. 75.1% [95% CI: 65.6%-82.3%]; respectively; overall P = 0.20; 5-year NRM: 21.7% [95% CI: 13.6%-30.9%] vs. 10.1% [95% CI: 4.4%-18.7%]; respectively; overall P = 0.12).