Easix score correlates with endothelial dysfunction biomarkers and predicts risk of acute graft-versus-host disease after allogeneic transplantation

Data from a recent trial showed that patients with tumor necrosis factor receptor 1 (TNFR1) ≥1300 ng/mL (HR 7.19, P = .006) and Log2 endothelial activation and stress index (EASIX) score ≥3 (HR 14.7, p <.001) at day 7 after allogeneic hematopoietic stem cell transplantation were more likely to develop acute GVHD with high predictive accuracy (C-index of 74% and 81%, respectively). In a validation cohort, patients with Log2-EASIX ≥3 on day 7 post-transplant presented with a significantly higher incidence of grade II-IV acute GVHD (HR 1.94, p = .004) independent of GVHD prophylaxis (HR 0.38, p = .004), conditioning regimen (HR 0.59, p =.02), and type of donor (HR 2.38, p = .014).