Recent Advances and Discoveries in the Mechanisms and Functions of CAR T Cells

Last Updated: Friday, July 17, 2026

This review discusses the major advances and changes made over the past 3 years to the understanding of CAR T-cell efficacy and safety, including mechanisms of toxicity and resistance as well as novel engineering and pharmaceutical interventions to overcome these challenges.

Nature Reviews Cancer

Frontiers in Immunotherapy

Smart control of CAR-T cells: Emerging strategies for safer and more effective cancer immunotherapy

Molecular Therapy

CDK4/6 inhibition enhances CAR-T cell therapy in solid tumors

Nature Medicine

In vivo generation of anti-BCMA CAR-T cells in relapsed or refractory multiple myeloma: A phase 1 study

Frontiers in Oncology

Safety and efficacy of CAR T-cell therapy in central nervous system lymphoma: A systematic review and meta-analysis

Journal of Translational Medicine

Asiaticoside enhances the antitumor efficacy of MSLN-targeted CAR-T cells in ovarian cancer

Trends in Cancer

In vivo CAR T cell engineering: Design principles and open questions

Blood Cancer Discovery

Multiomic and longitudinal dissection of immune dynamics associated with parkinsonism after ciltacabtagene autoleucel therapy

Blood Advances

Non-ICANS neurologic toxicity after BCMA CAR T: A systematic review and meta-analysis of 4630 multiple myeloma patients

Molecular Immunology

Navigating the frontier of CAR-T cell resistance: From underlying mechanisms to innovative therapeutic solutions

Cancer

Second-line chimeric antigen receptor T-cell therapy versus standard of care in relapsed or refractory large B-cell lymphoma: A systematic review and meta-analysis

CAR T-Cell Therapy Resource Center