Perspective: An International Fludarabine Shortage: Supply Chain Issues Impacting Transplantation and Immune Effector Cell Therapy Delivery

Maziarz et al. argue that resource scarcity can drive innovation in this perspective piece on the fludarabine shortage. Because some data have shown fludarabine to be essential to lymphodepletion for CAR T-cell therapies, exploration of alternative therapies and development of institutional algorithms for maintaining ongoing clinical trials are essential.