CAR-T Cell Therapy for Acute Myeloid Leukemia: Preclinical Rationale, Current Clinical Progress, and Barriers to Success

This report provides up-to-date information on outcomes and adverse effects from published and presented clinical trials of CAR-T cell therapy for AML and provides the preclinical rationale underlying these studies and antigen selection. The authors highlight currently active clinical trials and the potential improvements and caveats with these novel approaches.