Defective neutrophil clearance in JAK2V617F myeloproliferative neoplasms drives myelofibrosis via immune checkpoint CD24

Researchers investigated neutrophil homeostasis and cellular interactions in myeloproliferative neoplasms (MPN). Results showed that JAK2V617F neutrophils evade clearance and accumulate in JAK2V617F MPN through upregulation of CD24. The researchers concluded that CD24 may be a candidate innate immune checkpoint in MPN.