Characterization and prognostic implication of pulmonary hypertension among patients with myeloproliferative neoplasms

Researchers conducted a multicenter, retrospective cohort study to evaluate the effect of pulmonary hypertension on risk of progression to secondary myelofibrosis or acute leukemia in patients with myeloproliferative neoplasms. They found that over a median follow-up period of 51.2 months, pulmonary hypertension was associated with increased risk of progression to secondary myelofibrosis, leukemia progression, and major adverse cardiovascular events, but not all-cause death.