The antibody drug conjugate, belantamab-mafodotin, in the treatment of multiple myeloma: A comprehensive review

Last Updated: Wednesday, January 22, 2025

Multiple myeloma (MM) remains largely incurable, with relapses due to therapy resistance. This review highlights belantamab mafodotin, the first antibody-drug conjugate targeting BCMA, which is predominantly expressed in malignant plasma cells. By disrupting microtubules and signaling pathways, it shows promise in treating relapsed/refractory MM, as evidenced by pre-clinical and clinical DREAMM studies.

Blood and Lymphatic Cancer: Targets and Therapy

Clinical Lymphoma, Myeloma & Leukemia

Practical guidance on the clinical management of belantamab mafodotin for patients with relapsed/refractory multiple myeloma: Recommendations from the Middle East and North Africa expert panel

Future Oncology

Community hematologist/oncologist perspectives on minimal residual disease testing in patients with multiple myeloma

International Journal of Molecular Sciences

Breaking barriers: The role of the bone marrow microenvironment in multiple myeloma progression

HemaSphere

Early peripheral blood and bone marrow MRD as prognostic markers in quadruplet-treated multiple myeloma without transplant

Nature Cancer

ISB 2001 trispecific T cell engager shows strong tumor cytotoxicity and overcomes immune escape mechanisms of multiple myeloma cells

ASCO 2025

DREAMM-8 study of belantamab mafodotin plus pomalidomide and dexamethasone vs pomalidomide plus bortezomib and dexamethasone in relapsed/refractory multiple myeloma: A subgroup analysis in patients with high-risk cytogenetic features

Blood

Are we ready for an MRD-driven approach in multiple myeloma?

Frontiers in Oncology

Subcutaneous administration of isatuximab in patients with multiple myeloma by an on-body delivery system: Results of a nurse survey

The New England Journal of Medicine

Daratumumab or active monitoring for high-risk smoldering multiple myeloma

Journal of Clinical Oncology

Isatuximab subcutaneous by on-body delivery system vs isatuximab intravenous plus pomalidomide and dexamethasone in relapsed/refractory multiple myeloma: Phase 3 IRAKLIA study

Multiple Myeloma Resource Center