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Multiple Myeloma Resource Center

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First results from the RedirecTT-1 study with teclistamab (tec) + talquetamab (tal) simultaneously targeting BCMA and GPRC5D in patients (pts) with relapsed/refractory multiple myeloma (RRMM)

Last Updated: Tuesday, July 11, 2023

This is the first combination study of a BCMA- and GPRC5D-targeted bispecific antibody. This study evaluated the safety of a regimen combination of tec, the first BCMA-directed bispecific antibody approved for the treatment of triple-class exposed relapsed/refractory multiple myeloma, and tal, a bispecific antibody targeting the novel myeloma antigen GPRC5D. The study also aimed to identify a recommended phase 2 regimen for the combination. 

ASCO 2023
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News & Literature Highlights

Blood Cancer Journal

Outcomes of elderly patients with relapsed refractory multiple myeloma (RRMM) treated with teclistamab: A multicenter study from the U.S. Multiple Myeloma Immunotherapy Consortium

Bone Marrow Transplantation

Attitudes and perspectives of oncologists about measurable residual disease testing in multiple myeloma: Initiative for standardizing guidelines

Patient Preference and Adherence

Perspectives of healthcare providers and patients with relapsed/refractory multiple myeloma on treatment priorities and novel therapies

Targeted Oncology

Teclistamab dosing in responders: Modeling and simulation results from the MajesTEC-1 study in relapsed/refractory multiple myeloma

JCO Precision Oncology

Expanding the therapeutic reach of chimeric antigen receptor T-cells and bispecific T-cell engagers across solid tumors

Open Forum Infectious Diseases

Outcomes and risk factors for influenza and respiratory syncytial virus lower respiratory tract infections and mortality in patients with lymphoma or multiple myeloma: A 7-year retrospective cohort study

Cancer Reports

Efficacy and safety of quadruplet therapy in newly diagnosed transplant-eligible multiple myeloma: A systematic review and meta-analysis

Clinical Lymphoma, Myeloma & Leukemia

Expert perspectives on current challenges and emerging approaches for multiple myeloma: Narrative review of an inaugural bridging the gaps in leukemia, lymphoma, and multiple myeloma

Cancer Medicine

Application of GPRC5D targeting therapy in relapsed refractory multiple myeloma

The Lancet Haematology

Safety and activity of talquetamab in patients with relapsed or refractory multiple myeloma (MonumenTAL-1): A multicentre, open-label, phase 1-2 study

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