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Multiple Myeloma Resource Center

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Dynamic changes in symptom clusters and symptom networks in patients with multiple myeloma: Across-lagged network analysis

Last Updated: Thursday, September 25, 2025

This article explores how symptoms evolve in newly diagnosed multiple myeloma patients undergoing chemotherapy, identifying key symptom clusters like psychological distress and fatigue. The researchers used cross-lagged panel network analysis to pinpoint central symptoms, such as irritability and weight loss, that predict the occurrence of other symptoms. The findings offer valuable insights for nursing interventions aimed at improving symptom management in this patient population.

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News & Literature Highlights

The Lancet

Mezigdomide, carfilzomib, and dexamethasone versus carfilzomib and dexamethasone in patients with relapsed or refractory multiple myeloma (SUCCESSOR-2): a phase 3, open-label, randomised controlled trial

American Journal of Blood Research

Therapy-related B-cell acute lymphoblastic leukemia after treatment for multiple myeloma

Cancer Epidemiology

Occupational pesticide exposure and association of monoclonal gammopathy of undetermined significance in the Western Macroregion of Paraná

Molecular and Cellular Probes

The role of RNA modifications in the pathological mechanisms and therapeutic targeting of multiple myeloma

The FEBS Journal

Understanding and addressing resistance to IMiDs immunomodulatory compounds in multiple myeloma

Transplantation and Cellular Therapy

Trial in progress: QUINTESSENTIAL-2—a phase 3 Study of arlocabtagene autoleucel versus standard of care in adult patients with relapsed and refractory multiple myeloma (RRMM) exposed to lenalidomide

Journal of Translational Medicine

Long-term follow-up results of anti-BCMA CAR-T cell therapy combined with autologous hematopoietic stem cell transplantation in relapsed/refractory multiple myeloma with extramedullary disease

The Asco Post

Off-the-shelf CAR T-cell therapy produces deep, durable responses in heavily pretreated multiple myeloma

Cancer Medicine

Lenalidomide plus dexamethasone as first-line therapy in transplant-ineligible patients with multiple myeloma

BMC Infectious Diseases

Machine learning triumphs in differentiating fungal and bacterial infections

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