Association between diabetic control and progression of monoclonal gammopathy of undetermined significance to multiple myeloma

This retrospective cohort study of 11,061 US Veterans found that poor diabetic control, defined as HbA1c levels exceeding 7%, is associated with a significantly higher risk of MGUS progressing to multiple myeloma. The association was particularly strong among patients with Type 2 diabetes. Regular monitoring and optimization of diabetic control may help reduce progression risk.