From the publishers of JADPRO

Multiple Myeloma Resource Center

Advertisement

A novel two-part mixture model for the incidence and time course of cytokine release syndrome after elranatamab dosing in multiple myeloma patients

Last Updated: Thursday, February 20, 2025

This paper introduces a two-part mixture model using a Markov model to describe cytokine release syndrome (CRS) incidence and progression following elranatamab treatment, a bispecific antibody (BsAb). The model found that increased elranatamab exposure correlated with a higher probability of CRS, while premedication reduced this risk. This approach can characterize longitudinal CRS events and may help optimize dose-priming regimens for future BsAbs in clinical development.

Clinical Pharmacology and Therapeutics
Advertisement
News & Literature Highlights

Nature Cancer

ISB 2001 trispecific T cell engager shows strong tumor cytotoxicity and overcomes immune escape mechanisms of multiple myeloma cells

ASCO 2025

DREAMM-8 study of belantamab mafodotin plus pomalidomide and dexamethasone vs pomalidomide plus bortezomib and dexamethasone in relapsed/refractory multiple myeloma: A subgroup analysis in patients with high-risk cytogenetic features

Blood

Are we ready for an MRD-driven approach in multiple myeloma?

Frontiers in Oncology

Subcutaneous administration of isatuximab in patients with multiple myeloma by an on-body delivery system: Results of a nurse survey

The New England Journal of Medicine

Daratumumab or active monitoring for high-risk smoldering multiple myeloma

Journal of Clinical Oncology

Isatuximab subcutaneous by on-body delivery system vs isatuximab intravenous plus pomalidomide and dexamethasone in relapsed/refractory multiple myeloma: Phase 3 IRAKLIA study

Blood and Lymphatic Cancer

An updated indirect comparison of elranatamab versus a real-world external control arm in triple-class refractory multiple myeloma

Current Obesity Reports

Unraveling obesity and multiple myeloma: Insights from epidemiology and molecular mechanisms

Blood Cancer Journal

Outcomes of elderly patients with relapsed refractory multiple myeloma (RRMM) treated with teclistamab: A multicenter study from the U.S. Multiple Myeloma Immunotherapy Consortium

Bone Marrow Transplantation

Attitudes and perspectives of oncologists about measurable residual disease testing in multiple myeloma: Initiative for standardizing guidelines

Advertisement
Advertisement