Sex determines the presentation and outcomes in MPN and is related to sex-specific differences in the mutational burden
Last Updated: Friday, July 31, 2020
A recent analysis of 815 patients with MPN demonstrated that male sex is an independent predictor of poor outcomes. Men had higher rates of transformation to secondary myelofibrosis (HR 1.55; P = .013) and acute myeloid leukemia (HR 3.67; P < .001), and worse survival (HR 1.63; P = .001) independent of age, phenotype at diagnosis, and MPN-specific mutation compared with female patients, among other outcomes.
Advertisement
News & Literature Highlights
