From the publishers of JADPRO

Myeloproliferative Neoplasms Resource Center

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Sex determines the presentation and outcomes in MPN and is related to sex-specific differences in the mutational burden

A recent analysis of 815 patients with MPN demonstrated that male sex is an independent predictor of poor outcomes. Men had higher rates of transformation to secondary myelofibrosis (HR 1.55; P = .013) and acute myeloid leukemia (HR 3.67; P < .001), and worse survival (HR 1.63; P = .001) independent of age, phenotype at diagnosis, and MPN-specific mutation compared with female patients, among other outcomes.

 

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