Impact of anti-endothelial cell antibodies (AECAs) in patients with polycythemia vera and thrombosis

In a study of blood samples from 60 patients with polycythemia vera, those with thrombosis—compared to those without—had higher JAK2 V617F allele burden (75% vs. 25%; P <.001), Th17 levels (0.85 ⁺ 0.48% vs. 0.40 ⁺ 0.22%; P <.004), and IL-17 levels (6.30 ⁺ 0.8 pg/mL vs. 3.20 ⁺ 0.9 pg/mL; P <.005). Those with thrombosis also demonstrated a significantly higher enzyme-linked immunosorbent assay (ELISA) ratio in IgG anti-endothelial cell antibodies (AECAs; 25.1 ⁺ 10.1), compared to those without thrombosis (1.8 ⁺ 2.0) and the control group (1.7 ⁺ 2.2).