The role of irreversible pan-HER tyrosine kinase inhibitors in the treatment of HER2-positive metastatic breast cancer
Last Updated: Thursday, April 13, 2023
This review article takes a deep dive into mechanisms of the three irreversible tyrosine kinase inhibitors (TKIs) currently approved for the treatment of HER2-positive metastatic breast cancer—pyrotinib, neratinib, and afatinib—as well as key clinical trials of irreversible TKIs plus chemotherapy compared with reversible TKIs/chemotherapy and other regimens.
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